This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol or tacrolimus. Patients should be instructed to take Ziprasidone hydrochloride capsules with food for optimal absorption.
Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic treatment, which patients are likely to develop the syndrome. Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown. Tatsumi M, Jansen K, Blakely RD, Richelson E March 1999. "Pharmacological profile of neuroleptics at human monoamine transporters". European Journal of Pharmacology. What are the side effects of ziprasidone?
Ziprasidone functioned as an antagonist at the D 2, 5HT 2A, and 5HT 1D receptors, and as an agonist at the 5HT 1A receptor. Ziprasidone inhibited synaptic reuptake of serotonin and norepinephrine. Daniel DG, Zimbroff DL, Potkin SG, Reeves KR, Harrigan EP, Lakshminarayanan M May 1999. Ziprasidone hydrochloride capsules contain a monohydrochloride, monohydrate salt of Ziprasidone. This information is generalized and not intended as specific medical advice. If you have any health problems, consult your doctor or pharmacist before using this product.
After a single dose intramuscular administration, the peak serum concentration typically occurs at about 60 minutes after the dose is administered, or earlier. Steady state plasma concentrations are achieved within one to three days. Exposure increases in a dose-related manner and following three days of intramuscular dosing, little accumulation is observed. Because Ziprasidone hydrochloride can cause sleepiness, be careful when operating machinery or driving a motor vehicle. Carbamazepine is an inducer of CYP3A4; administration of 200 mg twice daily for 21 days resulted in a decrease of approximately 35% in the AUC of Ziprasidone. This effect may be greater when higher doses of carbamazepine are administered.
Guo JJ, Keck PE, Corey-Lisle PK, et al. January 2007. People with paranoid delusions are unreasonably suspicious of others. This can make it hard for them to hold a job, run errands, have friendships, and even go to the doctor. Roland Seifert; Thomas Wieland; Raimund Mannhold; Hugo Kubinyi; Gerd Folkers July 17, 2006. Cimetidine at a dose of 800 mg QD for 2 days did not affect Ziprasidone pharmacokinetics. Ziprasidone 10% compared to placebo 4%. Take this medication by mouth with food as directed by your doctor, usually twice daily. Swallow the capsules whole. What Is Ziprasidone Hydrochloride? Proliferative changes in the pituitary and mammary glands of rodents have been observed following chronic administration of other antipsychotic agents and are considered to be prolactin-mediated. Ziprasidone hydrochloride should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Its intramuscular injection form is approved for acute agitation in schizophrenic patients for whom treatment with just ziprasidone is appropriate. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristics of the patients is not clear. Ziprasidone has not been systematically studied, in animals or humans, for its potential for abuse, tolerance, or physical dependence. Only your doctor can decide if Ziprasidone hydrochloride capsules are right for you. This drug may also rarely cause significant weight gain and a rise in your blood cholesterol or triglyceride levels. These effects, along with diabetes, may increase your risk for developing heart disease. Discuss the risks and benefits of treatment with your doctor. Ziprasidone 40 and 80 mg twice daily with placebo, both dose groups were superior to placebo on the BPRS total score, the BPRS psychosis cluster, the CGI severity score and the PANSS total and negative subscale scores. Although 80 mg twice daily had a numerically greater effect than 40 mg twice daily, the difference was not statistically significant.
In the rat study, there was no evidence of an increased incidence of tumors compared to controls. In male mice, there was no increase in incidence of tumors relative to controls. Although not reported with Ziprasidone in premarketing trials, disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents. Ziprasidone hydrochloride and have their WBC followed until recovery. Heinz Lüllmann; Klaus Mohr 2006. Ziprasidone hydrochloride capsules may take a few weeks to work. It is important to be patient. Given the primary CNS effects of Ziprasidone, caution should be used when it is taken in combination with other centrally acting drugs. Call your doctor immediately if you take more than the amount of Ziprasidone hydrochloride capsules prescribed by your doctor. The following adverse reactions have been identified during post approval use of Ziprasidone hydrochloride. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. There are many products available. Many can be purchased without a prescription. Some products require a prescription. Consult your doctor or on the choice of the product that is best for you. The management of NMS should include: 1 immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy; 2 intensive symptomatic treatment and medical monitoring; and 3 treatment of any concomitant serious medical problems for which specific treatments are available. There is no general agreement about specific pharmacological treatment regimens for NMS. Other severe cutaneous adverse reactions, such as Stevens-Johnson syndrome, have been reported with Ziprasidone exposure. Severe cutaneous adverse reactions are sometimes fatal. Discontinue Ziprasidone if severe cutaneous adverse reactions are suspected. Positive, encouraging support from family and friends really helps, too. Keating AM, Aoun SL, Dean CE 2005. Refer to the storage information printed on the package. Protect from light and moisture. not store in the bathroom. Ziprasidone or any of the other ingredients of Ziprasidone hydrochloride capsules. minocin
Pooled data from short-term, placebo-controlled studies in schizophrenia are presented in Tables 1 to 2. Note that for the flexible dose studies in schizophrenia each subject is categorized as having received either low 20 to 40 mg BID or high 60 to 80 mg BID dose based on the subject's modal daily dose. Ask your pharmacist for a list of the ingredients. Ziprasidone is not approved for use in psychotic conditions related to dementia. Ziprasidone may increase the risk of death in older adults with dementia-related conditions. It is best to avoid consuming alcoholic beverages while taking Ziprasidone hydrochloride capsules. Ziprasidone absorption is optimally achieved when administered with food. Without a meal preceding dose, the bioavailability of the drug is reduced by approximately 50%. Although the mechanism of action of ziprasidone is not known, like other anti-psychotics, it inhibits communication between nerves of the brain. It does this by blocking receptors on the nerves for several neurotransmitters, the chemicals that nerves use to communicate with each other. While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first generation antipsychotic drugs. An elevated risk of acute dystonia is observed in males and younger age groups. Delusions are beliefs that seem real to you, even when there's strong evidence they aren't. order meclizine pills online mastercard meclizine
Antipsychotic drugs which include Ziprasidone hydrochloride may cause somnolence, postural hypotension, and motor and sensory instability, which could lead to falls and, consequently, fractures or other injuries. Citrome, L; Yang, R; Glue, P; Karayal, ON June 2009. "Effect of ziprasidone dose on all-cause discontinuation rates in acute schizophrenia and schizoaffective disorder: a post-hoc analysis of 4 fixed-dose randomized clinical trials. It is not known whether this drug passes into milk when applied to the skin. There are higher discontinuation rates for lower doses of Ziprasidone, which are also less effective than higher doses. Miceli JJ, Glue P, Alderman J, Wilner K 2007. "The effect of food on the absorption of oral ziprasidone". Psychopharmacology Bulletin. This sheet is only a summary. Ziprasidone hydrochloride capsules are prescription medicine and only your doctor can decide if it is right for you. If you have any questions or want more information about Ziprasidone hydrochloride capsules, talk with your doctor or pharmacist, address medical related queries to www. Ziprasidone may cause a condition that affects the heart rhythm QT prolongation. Although it's a lifelong illness, you can take medicines and find help to stop symptoms or make them easier to live with. United Kingdom: Royal Pharmaceutical Society of Great Britain. Remember to keep taking your capsules, even when you feel better. Take Ziprasidone hydrochloride capsules only as directed by your doctor. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. This drug may also rarely cause significant and a rise in your blood or triglyceride levels.
Ziprasidone was tested in the Ames bacterial mutation assay, the in vitro mammalian cell gene mutation mouse lymphoma assay, the in vitro chromosomal aberration assay in human lymphocytes, and the in vivo chromosomal aberration assay in mouse bone marrow. There was a reproducible mutagenic response in the Ames assay in one strain of S. typhimurium in the absence of metabolic activation. Positive results were obtained in both the in vitro mammalian cell gene mutation assay and the in vitro chromosomal aberration assay in human lymphocytes. Ziprasidone, and all patients experiencing these reactions were reported to recover completely. Upon appearance of rash for which an alternative etiology cannot be identified, Ziprasidone should be discontinued. Take Ziprasidone hydrochloride capsules with food. Ziprasidone hydrochloride capsules, 40 mg are size '4' capsules with dark blue opaque cap and dark blue opaque body, imprinted axially with "LU" on cap and "V52" on body in black ink, containing off-white to pinkish granular powder. In cases of severe extrapyramidal symptoms, anticholinergic medication should be administered. There is no specific antidote to Ziprasidone, and it is not dialyzable. The possibility of multiple drug involvement should be considered. Close medical supervision and monitoring should continue until the patient recovers. What brand names are available for ziprasidone? Ziprasidone may cause side effects. There have been reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress and feeding disorder in these neonates. These complications have varied in severity; while in some cases symptoms have been self-limited, in other cases neonates have required intensive care unit support and prolonged hospitalization. People in your neighborhood are plotting to harass you. PDF. FDA. July 19, 2000. People with schizophrenia who get counseling are also more likely to stick with their medications. Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company CHLIC. In Arizona, individual HMO plans are insured by Cigna HealthCare of Arizona, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company CGLIC or their affiliates see a that insure or administer group HMO, dental HMO, and other products or services in your state. Group Universal Life GUL insurance plans are insured by CGLIC. Life other than GUL accident, critical illness, and disability plans are insured or administered by Life Insurance Company of North America, except in NY, where insured plans are offered by Cigna Life Insurance Company of New York. All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico. The Journal of Pharmacology and Experimental Therapeutics. FDA Psychopharmacological Drugs Advisory Committee July 19, 2000. PDF. FDA. vistaril mail order shopping vistaril
Keep all regular medical and laboratory appointments. Side Effects List Imipramine Hcl side effects by likelihood and severity. Monti JM March 2010. "Serotonin 5-HT2A receptor antagonists in the treatment of insomnia: present status and future prospects. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Because Ziprasidone is highly metabolized, with less than 1% of the drug excreted unchanged, renal impairment alone is unlikely to have a major impact on the pharmacokinetics of Ziprasidone. People with schizophrenia aren't usually violent. But sometimes, paranoid delusions can make them feel threatened and angry. If someone is pushed over the edge, their actions usually focus on family members, not the public, and it happens at home. FDA, which approved the drug on February 5, 2001. To reduce the risk of and lightheadedness, get up slowly when rising from a sitting or lying position. Ziprasidone hydrochloride capsules, 80 mg are size '2' capsules with dark blue opaque cap and white opaque body, imprinted axially with "LU" on cap and "V54" on body in black ink, containing off-white to pinkish granular powder. This medication may increase a certain natural substance made by your body. If you have schizophrenia, you are more likely to develop diabetes than people who do not have schizophrenia, and taking ziprasidone or similar medications may increase this risk. Tell your doctor immediately if you have any of the following symptoms while you are taking ziprasidone: extreme thirst, frequent urination, extreme hunger, blurred vision, or weakness. It is very important to call your doctor as soon as you have any of these symptoms, because high blood sugar that is not treated can cause a serious condition called ketoacidosis. Ketoacidosis may become life-threatening if it is not treated at an early stage. Symptoms of ketoacidosis include dry mouth, nausea and vomiting, shortness of breath, breath that smells fruity, and decreased consciousness. topiramate online without rx
Ziprasidone may cause a a condition consisting of abnormal muscle movements, including tremor, shuffling, and uncontrollable movements 1 in 20 patients. Population pharmacokinetic analysis of schizophrenic patients enrolled in controlled clinical trials has not revealed evidence of any clinically significant pharmacokinetic interactions with benztropine, propranolol, or lorazepam. Ziprasidone at a dose of 40 mg twice daily administered concomitantly with lithium at a dose of 450 mg twice daily for 7 days did not affect the steady-state level or renal clearance of lithium. It affects how you think and behave. This can show up in different ways and at different times, even in the same person. The illness usually starts in late adolescence or young adulthood. Because of its potential for inducing hypotension, Ziprasidone may enhance the effects of certain antihypertensive agents. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Esophageal dysmotility and aspiration have been associated with antipsychotic drug use. Aspiration pneumonia is a common cause of morbidity and mortality in elderly patients, in particular those with advanced Alzheimer's dementia. As with other drugs that antagonize dopamine D 2 receptors, Ziprasidone elevates prolactin levels in humans. Alzheimer's dementia. Conditions that lower the seizure threshold may be more prevalent in a population of 65 years or older. Prolongation of the QTc interval is associated in some other drugs with the ability to cause torsade de pointes-type arrhythmia, a potentially fatal polymorphic ventricular tachycardia, and sudden death. In many cases this would lead to the conclusion that other drugs should be tried first. Group, BMJ, ed. March 2009.
This medication may rarely cause a very serious condition called neuroleptic syndrome NMS. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. If you notice any of these symptoms in your newborn especially during their first month, tell the doctor right away. Anything that can increase the chance of a heart rhythm abnormality should be avoided. Because of this, Ziprasidone hydrochloride should be used only after your doctor has considered this risk for Ziprasidone hydrochloride against the risks and benefits of other medications available for treating schizophrenia. The American Journal of Psychiatry. order vibramycin us canada uk
Any patient treated with atypical antipsychotics should be monitored for symptoms of hyperglycemia including polydipsia, polyuria, polyphagia, and weakness. Patients who develop symptoms of hyperglycemia during treatment with atypical antipsychotics should undergo fasting blood glucose testing. In some cases, hyperglycemia has resolved when the atypical antipsychotic was discontinued; however, some patients required continuation of antidiabetic treatment despite discontinuation of the suspect drug. Agranulocytosis including fatal cases has also been reported. Ziprasidone hydrochloride capsules, 20 mg are size '4' capsules with dark blue opaque cap and white opaque body, imprinted axially with "LU" on cap and "V51" on body in black ink, containing off-white to pinkish granular powder. Adverse reactions reported with Ziprasidone overdose included extrapyramidal symptoms, somnolence, tremor, and anxiety. Older adults may be more sensitive to the side effects of this drug, especially dizziness, uncontrolled movements, and QT prolongation see above. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor. The efficacy of oral Ziprasidone in the treatment of schizophrenia was evaluated in 5 placebo-controlled studies, 4 short-term 4- and 6-week trials and one maintenance trial. All trials were in adult inpatients, most of whom met DSM III-R criteria for schizophrenia. Each study included 2 to 3 fixed doses of Ziprasidone as well as placebo. Four of the 5 trials were able to distinguish Ziprasidone from placebo; one short-term study did not. Although a single fixed-dose haloperidol arm was included as a comparative treatment in one of the three short-term trials, this single study was inadequate to provide a reliable and valid comparison of Ziprasidone and haloperidol. Cardiovascular monitoring should commence immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias. If antiarrhythmic therapy is administered, disopyramide, procainamide, and quinidine carry a theoretical hazard of additive QT-prolonging effects that might be additive to those of Ziprasidone. Retrieved February 2, 2016. Ziprasidone also inhibits synaptic reuptake of serotonin and norepinephrine. Additionally, clinicians should be alert to the identification of other drugs that have been consistently observed to prolong the QTc interval. Such drugs should not be prescribed with Ziprasidone. The diagnostic evaluation of patients with this syndrome is complicated. Table 6 enumerates the incidence, rounded to the nearest percent, of treatment-emergent adverse reactions that occurred during acute therapy up to 6 weeks in predominantly patients with schizophrenia, including only those reactions that occurred in 2% or more of patients treated with Ziprasidone and for which the incidence in patients treated with Ziprasidone was greater than the incidence in placebo-treated patients. About FAERS: The FDA Adverse Event Reporting System FAERS is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. Using the two medicines together may cause an irregular heartbeat, which may be life-threatening. Leucht, S; et al. 2013. urmi.info propranolol
Wash and dry your hands before using. Clean and dry the affected area. If you are using the lotion or foam, shake it well just before using. If you are using the spray, check the product package to see if it needs to be shaken before each use. Apply a small amount of medication to the affected area and gently rub in, usually up to 4 times a day or as directed by your doctor or the product package. Dosage and length of treatment depends on the type of condition being treated. Do not bandage, cover, or wrap the area unless directed to do so by your doctor. PANSS on two consecutive days. Ziprasidone was significantly superior to placebo in time to relapse, with no significant difference between the different dose groups. There were insufficient data to examine population subsets based on age and race. Examination of population subsets based on gender did not reveal any differential responsiveness. There is a slight risk 1 in 1500 patients that ziprasidone by itself could significantly increase the QT interval. There is an even smaller risk 1 in 4000 patients that it could cause a potentially serious change in the rhythm of the heart. Tell your doctor if your condition persists or worsens. Ziprasidone is not removed by hemodialysis. Hypotension and circulatory collapse should be treated with appropriate measures such as intravenous fluids. If sympathomimetic agents are used for vascular support, epinephrine and dopamine should not be used, since beta stimulation combined with α 1 antagonism associated with Ziprasidone may worsen hypotension. Similarly, it is reasonable to expect that the alpha-adrenergic-blocking properties of bretylium might be additive to those of Ziprasidone, resulting in problematic hypotension. Sacher J, Mossaheb N, Spindelegger C, et al. June 2008. One case of priapism was reported in the premarketing database. While the relationship of the reaction to Ziprasidone use has not been established, other drugs with alpha-adrenergic blocking effects have been reported to induce priapism, and it is possible that Ziprasidone may share this capacity. Severe priapism may require surgical intervention. Adverse reactions during exposure were obtained by collecting voluntarily reported adverse experiences, as well as results of physical examinations, vital signs, weights, laboratory analyses, ECGs, and results of ophthalmologic examinations. Patients with an established diagnosis of diabetes mellitus who are started on atypical antipsychotics should be monitored regularly for worsening of glucose control. Undesirable alterations in lipids have been observed in patients treated with atypical antipsychotics. Pooled data from short-term, placebo-controlled studies in schizophrenia are presented in Tables 3-4.
Check the labels on all your medicines such as allergy or cough-and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. The government is spying on you. Stahl; Chiara Mattei; Maria Paola Rapagnani February 2011. Geodon ziprasidone hydrochloride US prescribing information. Pfizer Inc. Given these considerations, Ziprasidone should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia. Chronic antipsychotic treatment should generally be reserved for patients who suffer from a chronic illness that 1 is known to respond to antipsychotic drugs, and 2 for whom alternative, equally effective, but potentially less harmful treatments are not available or appropriate. In patients who do require chronic treatment, the smallest dose and the shortest duration of treatment producing a satisfactory clinical response should be sought. The need for continued treatment should be reassessed periodically. Australia Therapeutic Goods Administration. February 24, 2016. Your risk of dangerous changes in heart rhythm can be increased if you are taking certain other medicines and if you already have certain abnormal heart conditions. Therefore, it is important to tell your doctor about any other medicines that you take, including non-prescription medicines, supplements, and herbal medicines. You must also tell your doctor about any heart problems you have or have had. Ziprasidone 60 to 80 mg BID was -19. Retrieved October 6, 2016. You'll learn to test whether you're having delusions and how to ignore voices inside your head. QT prolongation, recent acute myocardial infarction, uncompensated heart failure, or cardiac arrhythmia. This list is not complete and there may be other drugs that should not be taken at the same time as ziprasidone. Tell your doctor about all medicines you use. Salmi P, Ahlenius S April 2000. "Sedative effects of the dopamine D1 receptor agonist A 68930 on rat open-field behavior. Serious. These medicines may interact and cause very harmful effects. As with other antipsychotics, long-term use of ziprasidone may lead to a potentially irreversible condition called tardive dyskinesia involuntary movements of the jaw, lips, and tongue. price cefpodoxime high
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Ziprasidone is known to cause activation into mania in some bipolar patients. Approximately two-thirds of Ziprasidone is metabolized via a combination of chemical reduction by glutathione and enzymatic reduction by aldehyde oxidase. There are no known clinically relevant inhibitors or inducers of aldehyde oxidase. Less than one-third of Ziprasidone metabolic clearance is mediated by cytochrome P450 catalyzed oxidation. Some side effects can be serious. Ziprasidone patients compared to no median weight change in placebo patients. trandate purchase store
Ziprasidone hydrochloride capsules contain Ziprasidone hydrochloride monohydrate, lactose monohydrate, pregelatinized maize starch, and magnesium stearate. Delayed-onset drug reaction called drug reaction with eosinophilia and systemic symptoms DRESS can occur with Ziprasidone. Signs of DRESS may include rash, fever, and swollen lymph nodes. Other severe cutaneous adverse reactions SCAR such as Stevens-Johnson syndrome can occur with Ziprasidone. Signs of Stevens-Johnson syndrome may include rash with blisters which could include ulcers in mouth, skin shedding, fever and target-like spots in the skin. DRESS and other SCAR are sometimes fatal; therefore, tell your doctor immediately if you experience any of these signs.
This drug may rarely make your blood sugar level rise, which can cause or worsen diabetes. Tell your doctor right away if you develop symptoms of high blood sugar, such as increased thirst and urination. If you already have diabetes, be sure to check your blood sugars regularly. Your doctor may need to adjust your diabetes medication, exercise program, or diet. Ketoconazole, a potent inhibitor of CYP3A4, at a dose of 400 mg QD for 5 days, increased the AUC and C max of Ziprasidone by about 35 to 40%. Other inhibitors of CYP3A4 would be expected to have similar effects. If you recognize that you're having trouble, you can be admitted voluntarily. But if you think you don't need help when you really do, the law may allow a doctor or other mental health professional to admit you involuntarily. microzide
Retrieved June 19, 2015. Keep Ziprasidone hydrochloride capsules and all medicines out of the reach of children. Hagop S. Akiskal; Mauricio Tohen June 24, 2011. If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered. The patient should be carefully monitored, since recurrences of NMS have been reported.